Journal: Frontiers in Physiology

Article Title: Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

doi: 10.3389/fphys.2012.00329

Figure Lengend Snippet: Quantified changes in mean arterial pressure (MAP) and heart rate (HR) measurements from baseline during one minute of noxious colorectal distension (CRD) in injured rats treated chronically (daily morning) with either Saline or GBP .

Article Snippet: Concurrent values for mean arterial blood pressure (MAP) and HR were recorded using DataQuest (Data Sciences International, Inc., St. Paul, MN) at 2 s intervals for 4 days pre-injury and 22 days following T4 spinal cord transection.

Techniques: Saline

Journal: Frontiers in Physiology

Article Title: Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

doi: 10.3389/fphys.2012.00329

Figure Lengend Snippet: Graphic examples of autonomic dysreflexia (AD) events detected over a 24-h period in an injured animal, employing the algorithm. Signals for mean arterial pressure (MAP) (A,B) and heart rate (HR) in beats per minute (C,D) from a saline-treated, injured rat 15 days following T4 spinal cord transection. In the MAP and HR traces, the horizontal red lines represent the baseline trace, while the blue lines correspond to the raw signals. The HR signal does not include a baseline, only the raw blue traces. In (B) and (D) , shown at higher magnification, the green lines indicate the beginning of an AD event, while red lines coincide with the end of the event.

Article Snippet: Concurrent values for mean arterial blood pressure (MAP) and HR were recorded using DataQuest (Data Sciences International, Inc., St. Paul, MN) at 2 s intervals for 4 days pre-injury and 22 days following T4 spinal cord transection.

Techniques: Saline

Journal: Frontiers in Physiology

Article Title: Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

doi: 10.3389/fphys.2012.00329

Figure Lengend Snippet: Graphic examples of conditions used to detect an autonomic dysreflexia (AD) event. (A) Filtered mean arterial pressure (MAP) signal with baseline (gray line) and three thresholds used in conditions for event. (B) Corresponding filtered heart rate (HR) signal within MAP event interval shows threshold for HR drop condition. Heart rate signal does not have a baseline.

Article Snippet: Concurrent values for mean arterial blood pressure (MAP) and HR were recorded using DataQuest (Data Sciences International, Inc., St. Paul, MN) at 2 s intervals for 4 days pre-injury and 22 days following T4 spinal cord transection.

Techniques:

Journal: Frontiers in Physiology

Article Title: Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

doi: 10.3389/fphys.2012.00329

Figure Lengend Snippet: Graphs representing both mean arterial pressure (A, MAP) and heart rate (B, HR in beats per minute) across days post-injury (DPI) gathered telemetrically over 24 h periods, beginning at 9:00 am following injections of either Saline or gabapentin (GBP). Due to the overall variability in both outcome measures, there were no significant differences between treatment groups for daily MAP and HR values. The conspicuous sustained elevation in both daily MAP and HR values beginning on days 14–15 post-injury that approached pre-injury values are interesting. n = 6 Saline; n = 5 GBP (50 mg/kg). Symbols represent group means ± SEM error bars.

Article Snippet: Concurrent values for mean arterial blood pressure (MAP) and HR were recorded using DataQuest (Data Sciences International, Inc., St. Paul, MN) at 2 s intervals for 4 days pre-injury and 22 days following T4 spinal cord transection.

Techniques: Saline